Pre-Existing Left Bundle Branch Block and Clinical Outcomes After Transcatheter Aortic Valve Replacement (JACC Asia April 2024)-Article: Pre-Existing Left Bundle Branch Block and Clinical Outcomes After Transcatheter Aortic Valve Replacement Title:

Article: Pre-Existing Left Bundle Branch Block and Clinical Outcomes After Transcatheter Aortic Valve Replacement Title:

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The research investigated the impact of pre-existing and new onset Left Bundle Branch Block (LBBB) on clinical outcomes post Transcatheter Aortic Valve Replacement (TAVR) in almost 6,000 patients. Pre-existing LBBB was linked to higher risks of 2-year all-cause and cardiovascular mortality, particularly heart failure death, compared to new onset LBBB. Propensity score analysis and subgroup analyses supported these associations, emphasizing the need for careful monitoring of pre-existing LBBB patients post-TAVR. New onset LBBB did not show significant mortality risks. The study recommended increased clinical attention for pre-existing LBBB patients and further research on treatment strategies. Limitations included potential bias and lack of detailed electrocardiographic data. The findings underscored the importance of considering LBBB presence in managing TAVR patients to mitigate adverse cardiovascular events.

Keywords

Left Bundle Branch Block

LBBB

Transcatheter Aortic Valve Replacement

TAVR

clinical outcomes

mortality risks

heart failure death

propensity score analysis

subgroup analyses

electrocardiographic data