Combination diuretic regimens to overcome loop diuretic resistance (DR) are commonly utilized with limited evidence.

Editors

Editor-in-Chief
Christopher O’Connor, MD, FACC

Executive Editor
Mona Fiuzat, PharmD, FACC

JACC Heart Failure CME Editors
Tariq Ahmad, MD, MPH
Adam DeVore, MD
Abhinav Sharma, MD
Mitchell Psotka, MD, PhD
Kishan Parikh, MD

Author
Zachary L. Cox, PHARMD

Target Audience

JACC Journal CME/MOC/ECME is intended for physicians who treat patients with cardiovascular disease.

Important Dates

Date of Release: February 24, 2020
Term of Approval/Date of CME/MOC/ECME Expiration: February 23, 2021

Learner Objectives

After reading this article the reader should be able to:

• Compare diuretic combination therapies for restoring diuretic response in acute heart failure complicated by diuretic resistance.
• Discuss the limitations of historical literature supporting the current understanding of diuretic therapy in acute heart failure complicated by diuretic resistance.
• Identify the role of the distal tubules in diuretic resistance and the rationale for the combination diuretic therapies studied.

Method of Participation and Claiming Credit
This ACC JACC Journals CME/MOC/ECME activity includes the reading of an article published in one of the JACC journals and the successful completion of self-assessment questions.  

Requesting AMA PRA Category 1 CME Credit™ and/or MOC or ECME credit for this Activity
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1. Read the article for which you wish to receive credit.
2. Answer the self-assessment questions. You need to have achieved a passing score of 70% or better in order for the Evaluation link to become activated. If you did not achieve a passing score, please click on the Posttest link in the left navigation bar and retake the exam.
3. After you complete the Evaluation, click on the Claim Credit button in the left navigation bar.
4. For CME or COP credit, enter the total amount of time you actually spent in the activity in the box provided. Please note that you may only claim once for this activity. Click Claim. 
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