Heart failure (HF) is a complex syndrome affecting millions of people around the world. Over the past decade, the therapeutic potential of targeting epigenetic regulators in HF has been discussed extensively. Recent advances in next-generation sequencing techniques have contributed substantial progress in our understanding of the role of DNA methylation, post-translational modifications of histones, adenosine triphosphate (ATP)-dependent chromatin conformation and remodeling, and non-coding RNAs in HF pathophysiology. In this review, we summarize epigenomic studies on human and animal models in HF.

Editors

Editor-in-Chief
Douglas L. Mann, MD, FACC

CME Editor
L. Kristin Newby, MD, FACC

Authors
Amanda Coniglio, MD
Michelle Kelsey, MD
Vishal Rao, MD

CME Information

Target Audience
JACC Journal CME/MOC/ECME is intended for physicians who treat patients with cardiovascular disease.

Important Dates
Date of Release: December 23, 2019
Term of Approval/Date of CME/MOC/ECME Expiration: December 22, 2020

Learner Objectives
After reading this article the reader should be able to:

• Explain the inheritance pattern of hypertrophic cardiomyopathy.
• Discuss the recommendations for screening first-degree family members of patients with inherited cardiomyopathies (e.g., hypertrophic cardiomyopathy).
• Compare the molecular mechanisms for epigenetic gene regulation.

Method of Participation and Claiming Credit
This ACCF JACC Journals CME/MOC/ECME activity includes the reading of an article published in one of the JACC journals and the successful completion of self-assessment questions.  

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