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Albuminuria and Heart Failure: JACC State-of-the-Art Review (JACC January 2023-2)

Although chronic kidney disease is characterized by low glomerular filtration rate (GFR) or albuminuria, estimated GFR (eGFR) is more widely utilized as a marker of risk profile in cardiovascular diseases, including heart failure (HF). The presence and magnitude of albuminuria confers a strong prognostic association in forecasting risk of incident HF as well as its progression, irrespective of eGFR. Despite the high prevalence of albuminuria in HF, whether it adds incremental prognostic information in clinical practice and serves as an independent risk marker, and whether there are any therapeutic implications of assessing albuminuria in patients with HF is less well-established. In this narrative review, we assess the potential role of albuminuria in risk profiling for development and progression of HF, strengths and limitations of utilizing albuminuria as a risk marker, its ability to serve in HF risk prediction models, and the implications of adopting albuminuria as an effective parameter in cardiovascular trials and practice.


Valentin Fuster, MD, PhD, MACC

CME Editor
Ragavendra R. Baliga, MD

Izza Shahid, MBBS
Muhammad Shahzeb Khan, MD, MSc 
Javed Butler, MD, MPH, MBA

Important Dates

Date of Release: January 16, 2023
Term of Approval/Date of CME/MOC Expiration: January 15, 2024

Availability: On-Demand
Expires on Jan 15, 2024
Cost: FREE
Credit Offered:
1 CME Credit
1 ABIM-MOC Point
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