Heart failure is a common disease with poor prognosis that is associated with cardiac immune cell infiltration and dysregulated cytokine expression. Recently, the clonal expansion of hematopoietic cells with acquired (i.e., nonheritable) DNA mutations, a process referred to as clonal hematopoiesis, has been reported to be associated with cardiovascular diseases including heart failure.

Editors

Editor-in-Chief
Douglas L. Mann, MD, FACC

CME Editor
L. Kristin Newby, MD, FACC

Author
Amanda Coniglio, MD

CME Information

Target Audience
JACC Journal CME/MOC/ECME is intended for physicians who treat patients with cardiovascular disease.

Important Dates
Date of Release: February 24, 2020
Term of Approval/Date of CME/MOC/ECME Expiration: February 23, 2021

Learner Objectives
After reading this article the reader should be able to:

• Identify genetic mutations associated with increased risk of cardiovascular disease.
• Discuss the impact of clonal hematopoiesis on heart failure.
• Discuss the current data regarding anti-inflammatory treatment for cardiovascular disease.

Method of Participation and Claiming Credit
This ACCF JACC Journals CME/MOC/ECME activity includes the reading of an article published in one of the JACC journals and the successful completion of self-assessment questions.  

Requesting AMA PRA Category 1 CME Credit™ and/or MOC or ECME credit for this Activity
To request credit, you must:

• Read the article for which you wish to receive credit.
• Answer the self-assessment questions. You need to have achieved a passing score of 70% or better in order for the Evaluation link to become activated. If you did not achieve a passing score, please click on the Posttest link in the left navigation bar and retake the exam.
• After you complete the Evaluation, click on the Claim Credit button in the left navigation bar.
• For CME or COP credit, enter the total amount of time you actually spent in the activity in the box provided. Please note that you may only claim once for this activity. Click Claim. 
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