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Circulating Progenitor Cells in Patients With Coronary Artery Disease and Renal Insufficiency: Clinical Research (JACC: Basic to Translational Science August 2020)

Patients with coronary artery disease and renal insufficiency (RI) (estimated glomerular filtration rate <60 ml/ min/1.73 m2) are at an increased risk of cardiovascular events. The contribution of regenerative capacity, measured as circulating progenitor cell (CPC) counts, to this increased risk is unclear. CPCs were enumerated as cluster of differentiation (CD) 45medþ mononuclear cells expressing CD34þ, CD133þ, CXCR4þ (chemokine [C-X-C motif] receptor 4), and VEGF2Rþ (vascular endothelial growth factor receptor 2) epitopes in 1,281 subjects with coronary artery disease (35% with RI). Patients with RI and low (<median) hematopoietic CPCs (CD34þ, CD34þ/CD133þ, and CD34þ/CXCR4þ) were at an increased risk of cardiovascular death or myocardial infarction events (hazard ratios: 1.75 to 1.80) during 3.5-year follow-up, while those with RI and high CPCs (>median) were at a similar risk as those without RI.


Douglas L. Mann, MD, FACC

CME Editors
Amanda Coniglio, MD
Michelle Kelsey, MD
Vishal Rao, MD

Michelle Kelsey, MD
Vishal Rao, MD
Amanda Coniglio, MD

Important Dates
Date of Release: August 24, 2020
Term of Approval/Date of CME/MOC/ECME Expiration: August 23, 2021

Availability: On-Demand
Available Aug 24, 2020 to Aug 23, 2021
Cost: FREE
Credit Offered: 1 CME Credit
1 ABIM-MOC Point
1 ECME Credit
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