Right ventricular (RV) size and function assessed by multi-modality imaging is associated with outcomes in a variety of cardiovascular diseases. Understanding RV anatomy and physiology is essential in appreciating the strengths and weaknesses of current imaging methods and gives these measurements greater context. Adaptation of the RV to different types and severity of stress, particularly over time, are specific to the cardiovascular disease process. Multi-modality imaging parameters, which determine outcomes, reflect the ability to image the initial and longitudinal RV response to stress. This article will review the standard and novel imaging methods for assessing RV function, and the impact of these parameters on outcomes in specific disease states.EditorsEditor-in-ChiefValentin Fuster, MD, PhD, MACCCME EditorRagavendra R. Baliga, MDAuthorRebecca T. Hahn, MDImportant DatesDate of Release: May 8, 2023Term of Approval/Date of CME/MOC Expiration: May 7, 2024