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Implications of Atrial Fibrillation for Guideline-Directed Therapy in Patients With Heart Failure: JACC State-of-the-Art Review (JACC March 2024-1)
Atrial fibrillation (AF) and heart failure (HF) are common cardiovascular conditions that frequently coexist. Among patients with HF, more than half also have AF. Both are associated with significant morbidity and mortality. Moreover, the prevalence of each is increasing globally, and this trend is expected to continue due to an aging population and increased life expectancy. Diagnosis of AF in a patient with HF is associated with greater symptom burden, more frequent hospitalizations, and a worse prognosis. Guideline-directed medical therapy (GDMT) for HF can impact the incidence of AF. Once present, AF can influence the efficacy of some components of GDMT for HF. In this review, we discuss the effect of GDMT for HF across the spectrum of ejection fraction on prevention of AF as well as the benefit of GDMT in patients with versus without AF.

Valentin Fuster, MD, PhD, MACC

CME Editor
Ragavendra R. Baliga, MD

Kelvin Bush, MD, FACC

Important Dates
Date of Release: February 26, 2024

Term of Approval/Date of CME/MOC Expiration: February 25, 2025  
Availability: On-Demand
Expires on Feb 25, 2025
Cost: FREE
Credit Offered:
1 CME Credit
1 ABIM-MOC Point
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