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Common Pathophysiology in Cancer, Atrial Fibrillation, Atherosclerosis, and Thrombosis (JACC: CardioOncology State-of-the-Art Review December 2021-1)
Common Pathophysiology in Cancer, Atrial Fibrillation, Atherosclerosis, and Thrombosis JACC: CardioOncology State-of-the-Art Review

Cardiovascular disease and cancer are the 2 leading causes of death worldwide. Emerging evidence suggests common mechanisms between cancer and cardiovascular disease, including atrial fibrillation and atherosclerosis. With advances in cancer therapies, screening, and diagnostics, cancer-specific survival and outcomes have improved. This increase in survival has led to the coincidence of cardiovascular disease, including atrial fibrillation and atherosclerosis, as patients with cancer live longer. Additionally, cancer and cardiovascular disease share several risk factors and underlying pathophysiologic mechanisms, including inflammation, cancer-related factors including treatment effects, and alterations in platelet function. Patients with cancer are at increased risk for bleeding and thrombosis compared with the general population. Although optimal antithrombotic therapy, including agent choice and duration, has been extensively studied in the general population, this area remains understudied in patients with cancer despite their altered thrombotic and bleeding risk. Future investigation, including incorporation of cancer-specific characteristics to traditional thrombotic and bleeding risk scores, clinical trials in the cancer population, and the development of novel antithrombotic and anti-inflammatory strategies on the basis of shared pathophysiologic mechanisms, is warranted to improve outcomes in this patient population.

JACC CardioOncology Editor-in-Chief and CME Editor
Bonnie Ky, MD, MSCE, FACC

Authors
Orly Leiva, MD
Duaa AbdelHameid, MD
Jean M. Connors, MD
Christopher P. Cannon, MD
Deepak L. Bhatt, MD, MPH

Important Dates

Date of Release: December 21, 2021    
Term of Approval/Date of CME/MOC/ECME Expiration: December 20, 2022 

Summary
Availability: On-Demand
Expires on Dec 20, 2022
Cost: FREE
Credit Offered:
1 CME Credit
1 ABIM-MOC Point
1 ECME Credit
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