The Amyloid Files: Cracking the Case – Evolving Strategies in Cardiac Amyloidosis-Case Review: Panel Discussion with Audience Question and Answer

Case Review: Panel Discussion with Audience Question and Answer

Video Transcription

Video Summary

The presentation revolves around an 80-year-old man diagnosed with wild-type ATTR cardiomyopathy, and discussions among a medical panel about his case management. The patient, exhibiting worsening peripheral neuropathy, atrial fibrillation, and other symptoms, is on metformin and low-dose furosemide, among other medications. His treatment includes tefamidus, empagliflozin, and spironolactone. Over two years, his symptoms worsen, prompting debate on whether to switch amyloid-specific therapies or include clinical trials. Discussions also encompass the challenges in distinguishing disease progression from other age-related health issues. There is consensus on potential therapy adjustments, although without definitive guidelines.

Keywords

ATTR cardiomyopathy

peripheral neuropathy

amyloid-specific therapies

clinical trials

disease progression