Pulsed Field vs Conventional Thermal Ablation for Paroxysmal Atrial Fibrillation: Recurrent Atrial Arrhythmia Burden (JACC July 2024-1)-Article: Pulsed Field vs Conventional Thermal Ablation for Paroxysmal Atrial Fibrillation: Recurrent Atrial Arrhythmia Burden

Article: Pulsed Field vs Conventional Thermal Ablation for Paroxysmal Atrial Fibrillation: Recurrent Atrial Arrhythmia Burden

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The study by the ADVENT Investigators compared the effectiveness of pulsed field ablation (PFA) versus thermal ablation for treating paroxysmal atrial fibrillation (AF). It found that both techniques had similar outcomes in terms of freedom from atrial arrhythmias over a year. However, post-ablation atrial arrhythmia burden above 0.1% was linked to reduced quality of life and increased need for interventions, with PFA showing lower burden levels. Patients who had previously failed antiarrhythmic drugs saw better results with PFA. The study emphasized that monitoring post-ablation arrhythmia burden is crucial for assessing treatment effectiveness and patient well-being. Additionally, it suggested that PFA could be more effective in reducing arrhythmia burden and improving outcomes for paroxysmal AF patients, especially those with a history of failed drug therapy. The research indicated that post-ablation arrhythmia burden is a more critical indicator of success than the traditional recurrence endpoint, highlighting the importance of incorporating this measure in future AF ablation trials for better evaluation of treatments and patient results.

Keywords

ADVENT Investigators

pulsed field ablation

thermal ablation

paroxysmal atrial fibrillation

atrial arrhythmias

post-ablation

antiarrhythmic drugs

arrhythmia burden

treatment effectiveness

patient outcomes