Prognostic Implications and Global Perspectives of Atrial Fibrillation in Patients Hospitalized for Heart Failure (JACC Heart Failure March 2025)-Article: Prognostic Implications and Global Perspectives of Atrial Fibrillation in Patients Hospitalized for Heart Failure

Article: Prognostic Implications and Global Perspectives of Atrial Fibrillation in Patients Hospitalized for Heart Failure

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The research study titled "Prognostic Implications and Global Perspectives of Atrial Fibrillation in Patients Hospitalized for Heart Failure" by Janice Y. Chyou and colleagues investigates the complex relationship between atrial fibrillation (AF) and heart failure (HF) in a global cohort. The study, conducted through the REPORT-HF registry, enrolled 13,401 patients from 44 countries who were hospitalized for acute HF, aiming to assess the implications of AF and HF on 1-year all-cause mortality.<br /><br />Key findings reveal that 58% of participants had a history of HF, and 39% had AF at the time of HF admission, with prevalence varying by left ventricular ejection fraction (LVEF) and race. The study highlights that combinations of prior HF, prior AF, and AF presentation influence mortality risk. Specifically, patients with a history of HF, who presented in AF and either had or did not have a prior diagnosis of AF, showed increased 1-year mortality rates compared to those without prior HF or AF.<br /><br />Distinct outcomes were noted for different subgroups: AF was more prevalent in patients with preserved ejection fractions and differed across racial groups, with lower rates in Asian and Black participants compared to White participants. The elevated risk of mortality was associated particularly with patients having a history of both HF and AF, emphasizing the importance of a prior HF history in the prognostic assessment.<br /><br />The study underscores the intertwined relationship of AF and HF, suggesting that understanding these associations can better stratify patients regarding their risk for poor outcomes. This large-scale analysis, being part of a global registry, offers significant insights into the global burden and prognosis of comorbid AF and HF, paving the way for targeted interventions and future research in managing patients with these conditions.

Keywords

Atrial Fibrillation

Heart Failure

Prognostic Implications

Global Perspectives

REPORT-HF registry

1-year Mortality

Left Ventricular Ejection Fraction

Racial Differences

Comorbid Conditions

Targeted Interventions