Prognostic Implication of Platelet Reactivity According to Procedural Complexity After PCI: Subanalysis of PTRG-DES Consortium (JACC Asia March 2024)-Article: Prognostic Implication of Platelet Reactivity According to Procedural Complexity After PCI: Subanalysis of PTRG-DES Consortium

Article: Prognostic Implication of Platelet Reactivity According to Procedural Complexity After PCI: Subanalysis of PTRG-DES Consortium

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The research study focused on the prognostic implications of high platelet reactivity (HPR) and procedural complexity in patients undergoing drug-eluting stent implantation. The study found that complex percutaneous coronary intervention (C-PCI) was associated with a higher risk of major adverse cardiac and cerebrovascular events (MACCE) and all-cause death over a 3-year follow-up period. Patients with HPR phenotype were found to have an increased risk of MACCE, regardless of procedural complexity. The study highlighted that the prognostic implication of HPR was consistent across different types and extents of procedural complexity. The findings suggest that potent P2Y12 inhibition may be crucial in overcoming the risk of atherothrombotic events related to HPR phenotype, especially in patients undergoing complex PCI. The study emphasizes the importance of individualized dual antiplatelet therapy strategies in high-risk patients to prevent adverse outcomes. Further research and large randomized trials are needed to validate the benefits of antiplatelet therapy dose escalation in reducing the ischemic risk in patients undergoing complex coronary interventions.

Keywords

high platelet reactivity

procedural complexity

drug-eluting stent implantation

major adverse cardiac events

cerebrovascular events

follow-up period

P2Y12 inhibition

dual antiplatelet therapy

atherothrombotic events

antiplatelet therapy dose escalation