Management of Coronary Vulnerable Plaque With Medical Therapy or Local Preventive Percutaneous Coronary Intervention-Article: Management of Coronary Vulnerable Plaque With Medical Therapy or Local Preventive Percutaneous Coronary Intervention

Article: Management of Coronary Vulnerable Plaque With Medical Therapy or Local Preventive Percutaneous Coronary Intervention

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The document discusses studies on lipid-lowering therapies, such as statins, ezetimibe, and PCSK9 inhibitors, in reducing plaque burden and improving stability in vulnerable coronary plaques. It highlights the efficacy of these treatments in reducing atheroma volume and lipid-rich plaques, potentially lowering the risk of cardiovascular events. Additionally, research on intravascular imaging techniques and preventive PCI for vulnerable plaques is discussed, along with ongoing trials like the PREVENT trial studying bioresorbable vascular scaffolds. The document also mentions the role of pharmacological agents like colchicine in reducing cardiovascular risk and emphasizes the need for further research to optimize the management of vulnerable plaques for better patient outcomes.

Keywords

lipid-lowering therapies

statins

ezetimibe

PCSK9 inhibitors

plaque burden

vulnerable coronary plaques

atheroma volume

intravascular imaging techniques

preventive PCI

PREVENT trial