Hybrid Magnetic Resonance Positron Emission Tomography Is Associated With Cardiac-Related Outcomes in Cardiac Sarcoidosis - JIMG April 2024-Article: Hybrid Magnetic Resonance Positron Emission Tomography Is Associated With Cardiac-Related Outcomes in Cardiac Sarcoidosis

Article: Hybrid Magnetic Resonance Positron Emission Tomography Is Associated With Cardiac-Related Outcomes in Cardiac Sarcoidosis

Back to course

Pdf Summary

A study involving 148 patients with suspected cardiac sarcoidosis (CS) assessed the utility of combined MR/PET imaging in predicting clinical outcomes. Different classifications based on MR and PET imaging data were created, with the MR(þ)5.7% PET(þ) FOCAL group showing the highest likelihood of meeting primary clinical endpoints. TNMRmax parameter effectively differentiated positive cases, and patients meeting clinical endpoints displayed higher TNMRmax values, indicating active CS and increased mortality risk. The study underscores the potential of MR/PET imaging in prognosis and treatment of CS, emphasizing the significance of TNMRmax as a prognostic indicator.<br /><br />The combined MR and PET imaging approach demonstrated stronger associations with clinical outcomes in CS patients compared to individual imaging modalities. New imaging subgroups based on PET tracer uptake patterns were introduced to enhance diagnosis specificity. The analysis of T2 values alongside other imaging parameters can aid in distinguishing pathological from physiological tracer uptake. Although limitations include absence of a gold standard for confirming cardiac inflammation and patient treatment variability, the study provides valuable insights into the role of hybrid MR/PET imaging in managing CS effectively. Further research with larger cohorts and longer follow-up periods is recommended for a deeper understanding of CS prognosis and the clinical benefits of combined imaging.

Keywords

cardiac sarcoidosis

MR/PET imaging

clinical outcomes

TNMRmax parameter

prognostic indicator

imaging subgroups

PET tracer uptake patterns

T2 values

cardiac inflammation

hybrid imaging