Evaluating Pericoronary Adipose Tissue Attenuation to Predict Cardiovascular Events: A Multicenter Study in East Asians (JACC Asia January 2025)-Article: Evaluating Pericoronary Adipose Tissue Attenuation to Predict Cardiovascular Events: A Multicenter Study in East Asians

Article: Evaluating Pericoronary Adipose Tissue Attenuation to Predict Cardiovascular Events: A Multicenter Study in East Asians

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The study explores the potential of Pericoronary Adipose Tissue Attenuation (PCATA) as a predictor for cardiovascular events in East Asian patients, specifically those of Japanese ethnicity. PCATA is an imaging biomarker obtained through coronary computed tomography angiography (CTA) that measures inflammation in the adipose tissue around coronary arteries. While previous studies have explored its efficacy in European populations, this research examines its utility in East Asians.<br /><br />Conducted across four Japanese hospitals, the study followed 1,270 patients with coronary ailments from 2011 to 2016. Researchers monitored composite cardiovascular events, such as cardiovascular death or acute coronary syndrome, over a median follow-up period of six years. Results indicated a significant association between high PCATA in the right coronary artery (RCA) and cardiovascular events. High RCA-PCATA patients were at an increased risk of major adverse cardiovascular events (MACE), including acute coronary syndromes and cardiovascular deaths.<br /><br />This association persisted even after accounting for conventional risk factors and adverse coronary CTA findings. The study highlights that a high RCA-PCATA serves as a significant independent predictor of future cardiovascular events, suggesting it could be a useful tool for identifying patients at higher risk of atherosclerotic cardiovascular disease in the East Asian demographic. However, the study also calls for more research to confirm these findings and consider potential ethnic differences in the relationship between PCATA and cardiovascular events. The researchers emphasize that while PCATA is linked to general coronary inflammation, further exploration is needed into its treatment implications and any differential effects due to ethnicity.

Keywords

Pericoronary Adipose Tissue Attenuation

PCATA

cardiovascular events

East Asian patients

Japanese ethnicity

coronary computed tomography angiography

coronary inflammation

right coronary artery

major adverse cardiovascular events

atherosclerotic cardiovascular disease