Clinical Spotlight Series: Hypertriglyceridemia & CV Health-6. Case Scenarios

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Video Summary

A 2026 dyslipidemia guideline case review highlights a 61-year-old man post-STEMI with diabetes and controlled LDL (54) but elevated triglycerides (295). The best next lifestyle step is adding twice-weekly resistance training; alcohol abstinence and very low-fat diets are reserved for much higher triglycerides. After lifestyle changes lowered TG to 225, icosapent ethyl is recommended to further reduce cardiovascular events (REDUCE-IT evidence) for TG 150–499. A second case describes familial chylomicronemia syndrome (LPL mutation) causing lifelong severe hypertriglyceridemia and recurrent pancreatitis, including high-risk pregnancies managed with plasma exchange and later ApoC3 therapy, emphasizing specialized very-low-fat dietary counseling.

Keywords

dyslipidemia

hypertriglyceridemia

icosapent ethyl

familial chylomicronemia syndrome

very-low-fat diet