Cardiac Damage Staging Predicts Outcomes in Symptomatic and Asymptomatic Aortic Stenosis After Aortic Valve Replacement-Article: Cardiac Damage Staging Predicts Outcomes in Symptomatic and Asymptomatic Aortic Stenosis After Aortic Valve Replacement

Article: Cardiac Damage Staging Predicts Outcomes in Symptomatic and Asymptomatic Aortic Stenosis After Aortic Valve Replacement

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The document presents a meta-analysis on the prognostic significance of a cardiac damage staging system in patients with aortic valve stenosis (AS) undergoing aortic valve replacement (AVR). It includes 16 studies with 14,499 patients categorized into different cardiac damage stages. The analysis reveals higher stages of cardiac damage are linked to increased all-cause mortality in both symptomatic severe AS and asymptomatic moderate/severe AS patients post-AVR. Mortality rates varied across different cardiac damage stages, indicating the importance of baseline cardiac damage staging in guiding therapy decisions to prevent irreversible cardiac damage and enhance long-term outcomes. The study emphasizes the relevance of considering cardiac damage staging in managing patients with AS to determine the necessity for early AVR or adjunctive pharmacotherapy. It highlights the potential of cardiac damage staging to aid risk assessment and the importance of future research to further establish its prognostic value and role in guiding interventions for patients with AS.

Keywords

meta-analysis

prognostic significance

cardiac damage staging system

aortic valve stenosis

aortic valve replacement

all-cause mortality

symptomatic severe AS

asymptomatic moderate/severe AS

baseline cardiac damage staging

risk assessment